C199
Sigma
CGS-15943
solid
| Synonym: | 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine |
| CAS Number: | 104615-18-1 |
| Linear Formula: | C13H8ClN5O |
| Molecular Weight: | 285.69 |
| MDL number: | MFCD01529897 |
| PubChem Substance ID: | 24277704 |
Description
| Biochem/physiol Actions | Highly potent, non-selective adenosine receptor antagonist. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble | |
| Gene Information | human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) |
| rat ... Adora1(29290), Adora2a(25369), Adora2b(29316) | |
| storage temp. | Room temp |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Li, J.m., et al., Adenosine A2a receptors increase arterial endothelial cell nitric oxide. J. Surg. Res. 80, 357-364, (1998) Abstract |
| Ongini, E, et al., Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7-10, (1999) Abstract | |
| Kim, Y.C., et al., Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J. Med. Chem. 39, 4142-4148, (1996) Abstract | |
| Williams, M., et al., Biochemical characterization of the triazoloquinazoline CGS 15943 a novel non-xanthine adenosine antagonist. J. Pharmacol. Exp. Ther. 241, 415, (1987) Abstract |
